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Related Experiment Videos

Increasing cord atrophy in early relapsing-remitting multiple sclerosis: a 3 year study.

W Rashid1, G R Davies, D T Chard

  • 1MS NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|December 20, 2005
PubMed
Summary

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Upper cervical cord atrophy (UCCA) develops early in relapsing-remitting multiple sclerosis (RRMS). Serial measurements detect this spinal cord atrophy in early-stage RRMS patients.

Area of Science:

  • Neurology
  • Neuroimaging
  • Multiple Sclerosis Research

Background:

  • Upper cervical cord atrophy (UCCA) is known in advanced multiple sclerosis (MS).
  • Its early detection in relapsing-remitting MS (RRMS) and relation to clinical course remain unclear.

Purpose of the Study:

  • To investigate the early detection of UCCA in RRMS patients.
  • To determine if early UCCA correlates with clinical outcomes.

Main Methods:

  • Twenty-seven RRMS patients (disease duration <3 years) and 20 controls were followed for 3 years.
  • Yearly assessments included UCCA, Expanded Disability Status Scale (EDSS), and MS Functional Composite Score (MSFC).
  • Statistical models adjusted for intracranial volume.

Main Results:

Related Experiment Videos

  • Significant UCCA decrease was observed in RRMS patients compared to controls (p=0.001).
  • EDSS significantly increased (p=0.008), while MSFC showed no significant change.
  • UCCA loss rate did not correlate with clinical changes or brain volume changes.

Conclusions:

  • Serial UCCA measurement can detect spinal cord atrophy in clinically early RRMS.
  • This finding highlights the potential of UCCA as an early biomarker in MS.