Related Experiment Videos
A case of vulvitis granulomatosa
Hiromi Tsuboi1, Mikio Masuzawa, Kensei Katsuoka
1Department of Dermatology, Kitasato University School of Medicine, Kanagawa, Japan.
The Journal of Dermatology
|December 20, 2005
Summary
Tranilast effectively treated a rare case of vulvitis granulomatosa, a genital manifestation of Merkerson-Rosenthal syndrome. This finding offers a new therapeutic option for this condition.
Area of Science:
- Dermatology
- Ophthalmology
- Genitourinary Medicine
Background:
- Merkerson-Rosenthal syndrome (MRS) is a rare condition characterized by granulomatous inflammation affecting the face, lips, and tongue.
- Genital involvement, specifically vulvitis granulomatosa, is an occasional manifestation of MRS.
- Tranilast has shown efficacy in treating other forms of granulomatous inflammation, including cheilitis and blepharitis.
Observation:
- This report details a case of an adult female patient presenting with vulvitis granulomatosa.
- The patient's condition involved granulomatous inflammation of the vulva.
Findings:
- The patient was successfully treated with tranilast.
- This represents a novel application of tranilast for managing genital manifestations of MRS.
Implications:
- Tranilast may be a viable therapeutic option for vulvitis granulomatosa and other genital MRS presentations.
- Further research is warranted to confirm the efficacy and safety of tranilast in this specific patient population.
- This case expands the known therapeutic applications of tranilast in managing rare granulomatous disorders.
Related Concept Videos
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
01:23Genital Herpes
Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:26Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
01:23Gastritis III: Clinical Manifestations and Management
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...