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Updated: Aug 14, 2026

An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
Cyclooxygenase 1 and 2 expressions in the human thyroid gland
Heung-Man Lee1, Seung-Kuk Baek, Soon-Young Kwon
1Department of Otolaryngology and Head and Neck Surgery, Korea University College of Medicine, Guro Hospital, 97 Gurodong-gil Guro-gu, 152-703, Seoul, Korea.
Abstract:
We investigated the expression of COX-1 and COX-2 in normal thyroid tissue, follicular adenoma and well-differentiated thyroid carcinomas and evaluated the difference in COX-1 and COX-2 expression. Ten normal thyroid tissues, ten follicular adenomas, ten papillary carcinomas and ten follicular carcinomas were analyzed by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) for expression of COX-1 and COX-2 mRNA. In addition, immunohistochemical staining was performed to find the expression of the two enzymes in normal thyroid tissues and thyroid neoplasia. Expression of COX-1 mRNA in the normal thyroid tissues, follicular adenomas and both well-differentiated carcinomas was similar and weak. However, COX-2 mRNA was strongly expressed in the well-differentiated carcinomas compared to those of normal thyroid tissue and follicular adenoma.
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