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Endurance training modulates the muscular transcriptome response to acute exercise.
Silvia Schmutz1, Christoph Däpp, Matthias Wittwer
1Department of Anatomy, University of Bern, Baltzerstrasse 2, 3000, Bern 9, Switzerland.
Pflugers Archiv : European Journal of Physiology
|December 20, 2005
Summary
A single bout of exercise shifts muscle gene expression towards a slow-oxidative phenotype in untrained individuals. Six weeks of endurance training attenuates this muscle transcript response during recovery.
Area of Science:
- Exercise Physiology
- Molecular Biology
- Muscle Adaptation
Background:
- Muscle gene expression adapts to exercise, influencing muscle phenotype.
- Understanding the time course of these adaptations is crucial for exercise science.
Purpose of the Study:
- To investigate the muscle transcriptomic response to a single bout of endurance exercise in untrained individuals.
- To determine if this response is altered after six weeks of endurance training.
Main Methods:
- Monitoring the expression of 220 transcripts in vastus lateralis muscle biopsies.
- Collecting samples at baseline, and 1, 8, and 24 hours post-exercise.
- Comparing responses between untrained and trained states.
Main Results:
- Untrained muscle showed a peak transcriptomic response 8 hours post-exercise, involving oxidative metabolism and glycolysis.
- Angiogenic and cell regulatory transcripts were transiently reduced 1 hour post-exercise.
- Training attenuated the post-exercise transcript induction and altered metabolic RNA levels.
Conclusions:
- A single endurance exercise bout induces a significant muscle transcriptomic shift towards a slow-oxidative phenotype in untrained individuals.
- Repeated endurance exercise modifies the muscle transcriptome, suggesting adaptation to training.
- The muscle's molecular response to exercise is dynamic and influenced by training status.