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Related Experiment Videos

Antibiotics and gastrointestinal colonization by vancomycin-resistant enterococci.

L B Rice1

  • 1Medical Service 111(W), Louis Stokes Cleveland VA Medical Center and Case Medical School, 10701 East Boulevard, Cleveland, OH 44106, USA. louis.rice@med.va.gov

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|December 20, 2005
PubMed
Summary

Minimizing certain antibiotics like extended-spectrum cephalosporins and ticarcillin-clavulanic acid can decrease glycopeptide-resistant enterococci (GRE) infections. Reducing anaerobic bacteria aids GRE colonization, highlighting the importance of antimicrobial stewardship.

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Glycopeptide-resistant enterococci (GRE) pose a significant nosocomial threat.
  • Certain antimicrobial agents are frequently associated with GRE colonization and infection.

Purpose of the Study:

  • To investigate the role of specific antimicrobial agents in GRE colonization and infection.
  • To elucidate the mechanisms by which certain antibiotics promote GRE persistence.

Main Methods:

  • Analysis of clinical studies linking antibiotic use to GRE.
  • Experimental mouse model of GRE gastrointestinal colonization.
  • Evaluation of antimicrobial agents' activity against enterococci and competing flora.

Main Results:

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  • Extended-spectrum cephalosporins and ticarcillin-clavulanic acid are commonly implicated in GRE.
  • Reducing anaerobic bacteria via antibiotic exposure promotes high-level GRE colonization.
  • Antimicrobials secreted in bile with low anti-enterococcal activity facilitate GRE establishment.

Conclusions:

  • Antimicrobial stewardship, particularly reducing use of implicated agents, can decrease GRE.
  • Disruption of gut microbiota by antibiotics is a key factor in GRE persistence.
  • Modifying prescribing practices is crucial for controlling GRE in healthcare settings.