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P wave duration and dispersion in multiple sclerosis

Abdulkadir Kocer1, Osman Karakaya, Ramazan Kargin

  • 1Dr Lütfi Kirdar Kartal Education and Research Hospital, Dept. of Neurology, Istanbul, Turkey. abdulkadirkocer@yahoo.com

Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
|December 20, 2005
PubMed
Abstract

Insights

Multiple sclerosis (MS) patients exhibit longer P wave duration and P wave dispersion (PWD) compared to healthy individuals. These findings suggest potential cardiovascular involvement in MS autonomic dysfunction.

Area of Science:

  • Cardiology
  • Neurology
  • Autonomic Dysfunction

Background:

  • Multiple sclerosis (MS) is linked to significant autonomic dysfunction and cardiovascular system involvement.
  • Previous research indicates a potential association between MS and cardiovascular alterations.

Purpose of the Study:

  • To investigate differences in P wave duration and P wave dispersion (PWD) between MS patients and healthy controls.
  • To assess potential cardiac electrophysiological changes in individuals with MS.

Main Methods:

  • A cohort of 31 MS patients and 33 healthy controls underwent 12-lead surface ECG recordings.
  • P wave duration and PWD were manually measured from ECG tracings.
  • Statistical analysis compared electrophysiological parameters between the two groups.

Main Results:

  • MS patients demonstrated a statistically significant higher maximum P wave duration compared to controls (p=0.004).
  • Mean PWD was significantly elevated in MS patients versus controls (p=0.01).
  • No significant difference was observed in minimum P wave duration between groups (p=0.2).

Conclusions:

  • P wave duration and PWD are significantly different in patients with multiple sclerosis compared to healthy subjects.
  • These findings highlight potential cardiac electrophysiological abnormalities in MS patients, possibly related to autonomic dysfunction.

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