Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Medication-overuse headache: pathophysiological insights.

Letizia Maria Cupini1, Paolo Calabresi

  • 1Ospedale Sant'Eugenio, Reparto di Neurologia, Unità Operativa Cefalee, Piazzale dell'Umanesimo, Rome, Italy.

The Journal of Headache and Pain
|December 20, 2005
PubMed
Summary

Medication overuse headache (MOH) can worsen primary headaches like migraine. Stopping the overused medication is crucial for recovery and prevention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics and causes of recurrent ischemic events in minor ischemic stroke and TIA in the READAPT study.

Journal of the neurological sciences·2025
Same author

Real-world outcomes following dual antiplatelet therapy in mild-to-moderate ischemic stroke with anterior versus posterior circulation infarct: a READAPT study propensity matched analysis.

Therapeutic advances in neurological disorders·2025
Same author

Genetic characterization of the endocannabinoid system and psychiatric features in patients with migraine and medication overuse headache.

Cephalalgia : an international journal of headache·2025
Same author

Admission systolic blood pressure and short-term outcomes after dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack.

Therapeutic advances in neurological disorders·2025
Same author

Effectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study.

European stroke journal·2025
Same author

Real-World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis-Insights From the READAPT Study.

European journal of neurology·2025

Area of Science:

  • Neurology
  • Pharmacology
  • Pain Medicine

Background:

  • Medication overuse headache (MOH) is a significant clinical issue.
  • Regular use of acute symptomatic medications can aggravate primary headaches such as migraine and tension-type headache.
  • MOH is a leading cause of chronic migraine-like syndromes.

Purpose of the Study:

  • To analyze the mechanisms underlying sensitization in MOH.
  • To compare these mechanisms with those reported in other forms of drug addiction.
  • To emphasize the importance of awareness and prevention strategies for MOH.

Main Methods:

  • Review of existing literature on MOH etiology and mechanisms.
  • Comparative analysis of sensitization pathways in MOH and drug addiction.
  • Discussion of clinical management strategies, focusing on medication cessation.

Main Results:

  • Commonly overused medications include barbiturate and caffeine-containing analgesics.
  • Triptans, while less frequent, are also potential inducers of MOH.
  • Several theories explain MOH etiology, including central sensitization, direct medication effects on pain inhibition, serotonin level alterations, cellular adaptation, and changes in the periaqueductal gray matter.

Conclusions:

  • Cessation of the overused medication is the primary management approach for MOH.
  • Improvement in MOH is unlikely without discontinuing the offending medication.
  • Raising awareness and focusing on prevention are the most effective management strategies.

Related Experiment Videos