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Updated: Aug 14, 2026

A Mouse Model of Single and Repetitive Mild Traumatic Brain Injury
Published on: June 20, 2017
Post-traumatic headache from moderate head injury
Davide Moscato1, Maria I Peracchi, Giovanni Mazzotta
1Headache Centre San Carlo IDI Rome, Via Aurelia 275, Rome, Italy. d.moscato@idi.it
Insights
Post-traumatic headache (PTH) is common after severe head injuries but its link to mild trauma is unclear. Studies suggest PTH after mild head trauma is rare, questioning its existence as a distinct condition.
Area of Science:
- Neurology
- Trauma Medicine
- Headache Disorders
Background:
- Post-traumatic headache (PTH) frequently occurs in children following severe head injuries, often as part of a broader post-traumatic syndrome.
- Establishing a causal link for PTH after mild head trauma presents significant challenges.
- The independent nosological status of PTH, particularly after minor head injuries, remains uncertain.
Purpose of the Study:
- To investigate the incidence of post-traumatic headache (PTH) in patients presenting to an emergency department after head trauma.
- To compare PTH incidence in a French hospital with data from Italian headache centers.
- To evaluate the evidence supporting PTH as a distinct entity following mild head trauma.
Main Methods:
- A one-year prospective study of patients with head trauma in the emergency ward of Saint Charles of Nancy Hospital.
- Comparison of findings with data from four Italian headache centers examining 1,656 patients.
- Analysis of acute and chronic PTH incidence in relation to trauma severity.
Main Results:
- At Saint Charles of Nancy Hospital, 98 patients with moderate head trauma experienced PTH; 18 acute and 26 chronic cases, with most resolving within six months.
- In Italian headache centers, 3.2% of 1,656 patients had PTH, comprising 25 acute and 29 chronic cases.
- The data indicate a low incidence of PTH following mild head trauma.
Conclusions:
- The findings suggest that post-traumatic headache (PTH) is infrequently associated with mild head trauma.
- The low incidence challenges the classification of PTH as a distinct nosological entity after minor head injuries.
- Further research is needed to clarify the pathophysiology and diagnostic criteria for PTH, especially in mild trauma cases.
Abstract:
The onset of post-traumatic headache occurs frequently in children, where it is often caused by severe head injuries, therefore, it is part of a post-traumatic syndrome, rather than of an independent headache and in this case no cause is clearly evident. The problem, conversely, arises in post-traumatic headache after a light trauma, since it is difficult to establish the cause-effect link. We have studied PTH incidence for one year in the patients of the emergency ward of the Saint Charles of Nancy Hospital, compared to the activity of 4 Italian headache centres. At the Saint Charles of Nancy Hospital of 98 patients with PTH after a moderate head trauma, 18 had acute and 26 chronic PTH, the majority ceased after six months. In the Italian headache centres 1,656 patients were examined, of these 3.2% suffered from PTH: 25 acute, 29 chronic. These data confirm the poor evidence of PTH after a light trauma and lead to doubt of the existence of this nosological entity.
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