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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Clinic-based study of family history of vascular risk factors and migraine

Grace Yoon1, Susan Baggaley, Peter Bacchetti

  • 1Division of Medical Genetics, Department of Pediatrics, University of California, San Francisco, CA 94143-2922, USA.

The Journal of Headache and Pain
|December 20, 2005
PubMed

Insights

Migraine with aura (MA) and migraine without aura (MO) showed no difference in family history of vascular risk factors. Chronic migraine (CM) patients had less family history of stroke, suggesting a neuronal origin.

Area of Science:

  • Neurology
  • Vascular Neurology
  • Epidemiology

Background:

  • Migraine is a common neurological disorder.
  • Family history of vascular risk factors may offer insights into migraine pathophysiology.
  • Studying relatives can circumvent age-related limitations in migraine patients.

Purpose of the Study:

  • To compare family history of vascular risk factors in migraine with aura (MA) versus migraine without aura (MO).
  • To assess family history of vascular risk factors in chronic migraine (CM) versus other headache types.

Main Methods:

  • Cross-sectional study at the University of Utah.
  • Involved adult migraine patients diagnosed using International Headache Society criteria.
  • Assessed family history of stroke, hypertension, diabetes, and hypercholesterolemia in first or second-degree relatives.

Main Results:

  • No significant difference in family history of vascular risk factors between MA and MO groups (adjusted OR 1.04, 95% CI 0.61-1.78).
  • Chronic migraine (CM) was associated with a decreased risk of family history of stroke (OR=0.11, 95% CI 0.02-0.87, p=0.036).
  • CM patients were more likely to have a negative family history of stroke compared to other headache types.

Conclusions:

  • Family history of vascular risk factors does not differentiate between MA and MO.
  • The reduced family history of stroke in CM suggests a potential neuronal, rather than vascular, basis for this migraine subtype.

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