Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histocompatibility antigens and solid malignant neoplasms.

J L Tarpley, P B Chretien, G N Rogentine

    Archives of Surgery (Chicago, Ill. : 1960)
    |March 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Roles of Fasciotomy and Peripheral Nerve Decompression in Electric Burn Patients: A Systematic Review and Meta-Analysis.

    Microsurgery·2025
    Same author

    EURAPS Editorial 2019: "Bisturi, please" said the surgeon to the scrub nurse.

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2019
    Same author

    Ketamine : A safe and effective anesthetic agent for children in the developing world.

    Pediatric surgery international·2013
    Same author

    Gram stain microbiological pattern of upper extremities suppuration at Baptist Medical Centre, Ogbomoso Nigeria: a fifteen month review.

    African journal of medicine and medical sciences·2011
    Same author

    Otto Hilgenfeldt (1900-1983): tribute to an important pioneer of European hand surgery.

    The Journal of hand surgery, European volume·2011
    Same author

    Comparison of the Semmes-Weinstein monofilaments with the Pressure-Specifying Sensory Device.

    Restorative neurology and neuroscience·2011

    Certain human leukocyte antigen (HLA) types are linked to specific solid tumors. For example, HLA-8 is more common in squamous cell carcinoma, melanoma, and adenocarcinoma, while HLA-5 is associated with connective tissue sarcomas.

    Area of Science:

    • Immunogenetics
    • Oncology
    • Human Leukocyte Antigen (HLA) System

    Background:

    • Histocompatibility antigen phenotypes, specifically Human Leukocyte Antigen (HLA) types, play a crucial role in immune responses.
    • Understanding the association between HLA types and various cancers can provide insights into tumor genesis and potential therapeutic targets.

    Purpose of the Study:

    • To investigate the relationship between specific HLA antigen phenotypes and the occurrence of solid malignant neoplasms.
    • To determine if certain HLA types are more prevalent in cancer patients compared to healthy individuals.

    Main Methods:

    • Determined HLA typing for 633 cancer patients and 489 healthy controls.
    • Compared the frequencies of specific HLA antigens between the patient cohort and the control group.

    Related Experiment Videos

  • Analyzed antigen frequencies based on cancer type, time of diagnosis, and post-treatment intervals.

    • Main Results:

    • A significant elevation of HLA-8 was observed in patients with squamous cell carcinoma, melanoma, and adenocarcinoma.
    • Salivary gland adenocarcinoma showed the highest incidence of HLA-8 (67% in patients vs. 17% in controls).
    • A threefold increase in HLA-5 was detected in patients with connective tissue sarcomas (28% vs. 9% in controls).

    Conclusions:

    • Specific HLA antigen phenotypes are associated with an increased frequency in certain solid malignant neoplasms.
    • These associations may offer valuable clues regarding the etiology and pathogenesis of these tumors.
    • Further research into HLA-antigen associations could inform cancer research and treatment strategies.