Related Experiment Video

Updated: Aug 2, 2026

The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity
07:00

The ex vivo Isolated Skeletal Microvessel Preparation for Investigation of Vascular Reactivity

Published on: April 28, 2012

Analysis of vasoactivity of local pH, PCO2 and bicarbonate on pial vessels

H A Kontos, A J Raper, J L Patterson

    Stroke
    |May 1, 1977
    PubMed

    More Related Videos

    Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices13:32

    Videomorphometric Analysis of Hypoxic Pulmonary Vasoconstriction of Intra-pulmonary Arteries Using Murine Precision Cut Lung Slices

    Published on: January 14, 2014

    Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine12:37

    Surgical Placement of Catheters for Long-term Cardiovascular Exercise Testing in Swine

    Published on: February 9, 2016

    Related Concept Videos

    Assessment of Diffusion and Perfusion01:17

    Assessment of Diffusion and Perfusion

    Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
    The Role of Diffusion in Respiration
    Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...
    Local Anesthetics: Pharmacokinetics01:13

    Local Anesthetics: Pharmacokinetics

    The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
    Oxygen Transport in the Blood01:27

    Oxygen Transport in the Blood

    Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
    Carbon Dioxide Transport in the Blood01:19

    Carbon Dioxide Transport in the Blood

    Carbon dioxide (CO2) transport in the blood is critical to human physiology. On average, our body cells produce around 200 mL of CO2 per minute, precisely the quantity expelled by the lungs. This process involves the transportation of CO2 from the tissue cells to the lungs in three primary forms.
    Forms of CO2 Transport
    1. Dissolved in plasma: A small percentage (7-10%) of CO2 is transported and dissolved directly in the plasma.
    2. Carbaminohemoglobin: Just over 20% of CO2 is chemically bound to...
    Chemical Factors Affecting Respiration Centers01:31

    Chemical Factors Affecting Respiration Centers

    Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
    CO2 has a potent influence on respiration and is strictly regulated. Under...
    Diagnosing Acidosis and Alkalosis01:24

    Diagnosing Acidosis and Alkalosis

    Diagnosing acid-base imbalances involves systematically analyzing arterial blood samples, focusing on three key measurements: pH, bicarbonate (HCO3−) concentration, and carbon dioxide partial pressure (PCO2). This analysis follows a four-step process that helps identify the imbalance's underlying cause and nature.
    First, the pH level is assessed to determine whether the blood pH is normal (7.35–7.45), low (acidosis), or high (alkalosis).
    Next, the PCO2  and HCO3−  values are examined to...