Risk factors for hospitalization in children with acute diarrhea: a case control study

S Songül Yalçin1, Samil Hizli, Kadriye Yurdakök

  • 1Social Pediatrics Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Insights

Key risk factors for acute diarrhea hospitalization in young children include dehydration, high purging rates, and lack of breastfeeding. Early medical attention and continued breastfeeding are crucial for preventing severe illness in infants and toddlers.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Acute diarrhea is a leading cause of childhood illness and hospitalization globally.
  • Identifying risk factors for hospitalization is crucial for effective prevention and management strategies.

Purpose of the Study:

  • To identify significant risk factors associated with hospitalization in children aged 0-24 months presenting with acute diarrhea.
  • To inform clinical practice and public health interventions aimed at reducing pediatric diarrhea-related hospital admissions.

Main Methods:

  • A retrospective case-control study was conducted at a Diarrheal Diseases Training and Treatment Center.
  • Hospitalized children (cases) were compared with non-hospitalized children (controls) admitted consecutively.
  • Data on clinical history and physical examination were collected and analyzed using univariate and multiple logistic regression.

Main Results:

  • Univariate analysis indicated higher rates of purging, vomiting, malnutrition, dehydration, fever, and lack of breastfeeding in hospitalized children.
  • Multiple logistic regression identified high purging rate (more than 8/day), presence of dehydration, and absence of breastfeeding as statistically significant risk factors for hospitalization.
  • Age, sex, height, blood in stool, and duration of diarrhea did not significantly differ between groups.

Conclusions:

  • High purging rate, dehydration, and absence of breastfeeding are critical indicators for potential hospitalization in young children with acute diarrhea.
  • Mothers should be advised to seek prompt medical care for children exhibiting these symptoms and to maintain breastfeeding up to 24 months.
  • Further multi-center studies are recommended to validate these findings and explore other potential risk factors.

Related Concept Videos

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents01:18

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...