Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emollients in a propanol-based hand rub can significantly decrease irritant contact dermatitis.

Günter Kampf1, Walter Wigger-Alberti, Volker Schoder

  • 1Bode Chemie GmbH & Co., Scientific Affairs, Melanchthonstr. 27, 22525 Hamburg, Germany. guenter.kampf@bode-chemie.de

Contact Dermatitis
|December 21, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical site infection definitions consensus: a first step toward improving prevention in veterinary medicine.

American journal of veterinary research·2025
Same author

VER-01 Shows Enhanced Gastrointestinal Tolerability, Superior Pain Relief, and Improved Sleep Quality Compared to Opioids in Treating Chronic Low Back Pain: A Randomized Phase 3 Clinical Trial.

Pain and therapy·2025
Same author

Full-spectrum extract from Cannabis sativa DKJ127 for chronic low back pain: a phase 3 randomized placebo-controlled trial.

Nature medicine·2025
Same author

Equivalent reduction of Escherichia coli by rinsing hands with cold and warm water.

GMS hygiene and infection control·2025
Same author

Does the COVID-19 Vaccination Reduce the Risk to Transmit SARS-CoV-2 to Others?

Advances in experimental medicine and biology·2024
Same author

Effect of Face Masking on Transmission of SARS-CoV-2.

Advances in experimental medicine and biology·2024

Adding emollients to propanol-based hand rubs significantly reduces skin dryness and erythema. This formulation helps prevent irritant contact dermatitis, even with frequent use.

Area of Science:

  • Dermatology
  • Contact Dermatitis
  • Formulation Science

Background:

  • Frequent use of alcohol-based hand sanitizers can lead to skin dryness and irritation.
  • Propanol-based hand rubs are common, but their emollient content can impact skin health.
  • Atopic individuals may be more susceptible to skin irritation from hand hygiene products.

Purpose of the Study:

  • To evaluate the impact of emollients in a propanol-based hand rub on skin dryness and erythema.
  • To compare the efficacy of a hand rub with emollients versus one without.
  • To assess if atopic status influences the effects of the hand rub formulations.

Main Methods:

  • Prospective, randomized, controlled, double-blind trial with 35 subjects.
  • Two propanol-based hand rub formulations (with and without 0.81% emollients) were applied twice daily for 2 weeks.

Related Experiment Videos

  • Skin assessments for erythema and dryness were performed using a standard visual scale.

    • Main Results:

    • The hand rub containing emollients showed significantly lower scores for erythema and dryness compared to the one without (P=0.022).
    • The mean sum score for skin irritation was 0.8 (emollients) versus 1.5 (no emollients).
    • No significant differences in product effects were observed between atopic and non-atopic subjects.

    Conclusions:

    • Incorporating emollients into propanol-based hand rubs effectively mitigates irritant contact dermatitis.
    • This formulation strategy is beneficial for maintaining skin integrity under conditions of frequent use.
    • The addition of emollients offers a significant improvement in skin tolerability for hand hygiene products.