Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Internet-based Profiler system as integrative framework to support translational research.

Robert Kim1, Francesca Demichelis, Jeffery Tang

  • 1Department of Pathology, Brigham and Women's Hospital, Boston, USA. rkim7@partners.org

BMC Bioinformatics
|December 21, 2005
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial transcriptomic mapping of canine osteosarcoma reveals immune microenvironment features linked to survival.

Communications biology·2026
Same author

CholeraSeq: a comprehensive genomic pipeline for cholera surveillance and near real-time outbreak investigation.

Bioinformatics (Oxford, England)·2025
Same author

Intrinsic Alterations of the Inflammatory Pathways in Primary Canine Atopic Keratinocytes.

Allergy·2025
Same author

Sex Differences in Brain Transcriptomes of Juvenile Cynomolgus Macaques.

Biomolecules·2025
Same author

Deletion of metal transporter Zip14 reduces major histocompatibility complex II expression in murine small intestinal epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Phylogenetic-informed graph deep learning to classify dynamic transmission clusters in infectious disease epidemics.

Bioinformatics advances·2024

Researchers developed a robust process for molecular biomarker discovery using tissue microarray (TMA) technology and the Profiler database. This integrated system enhances diagnostic and prognostic tool development for clinical applications.

Area of Science:

  • Biomedical research
  • Translational science
  • Molecular pathology

Background:

  • Translational research bridges basic science and clinical applications.
  • Tissue microarray (TMA) technology enables efficient analysis of numerous patient samples.
  • The Profiler internet-database tool facilitates tracking and evaluation of TMA experiments.

Purpose of the Study:

  • To describe a developed process for creating molecular biomarkers.
  • To integrate TMA technology with a database for biomarker development.
  • To present a system evolved over five years at two academic institutions.

Main Methods:

  • Integration of tissue microarray (TMA) technology.
  • Utilization of the Profiler internet-database system for experiment tracking and data management.

Related Experiment Videos

  • Empirical development and refinement of the process over five years.

    • Main Results:

    • The system is compatible with multiple organ systems and supports 656 TMA experiments with 63,311 digital images.
    • 68 pathologists accessed the system, with some linking clinical data for over 500 patients.
    • The Profiler database stores 170,000 data points, enabling analysis of single or multiple TMA experiments.

    Conclusions:

    • A robust process for molecular biomarker development using TMA and an internet-based database has been established.
    • The system is extendable to other molecular data types and is available for academic licensing.
    • This integrated approach streamlines the development of diagnostic and prognostic molecular biomarkers.