Interactions among the components of the interleukin-10 receptor complex

Christopher D Krause1, Erwen Mei, Olga Mirochnitchenko

  • 1Department of Molecular Genetics, Microbiology, and Immunology, The University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854, USA.

Summary

The interleukin-10 (IL-10) receptor complex is preassembled, unlike the interferon-gamma (IFN-gamma) receptor. This IL-10 receptor shows no major structural changes upon IL-10 binding, suggesting preassembly is common for Class 2 cytokine receptors.

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