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Updated: Aug 14, 2026

Generation of Monoclonal Antibodies Against Natural Products
Published on: April 6, 2019
How antibodies act as natural adjuvants
Andrew Getahun1, Birgitta Heyman
1Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden. andrew.getahun@genpat.uu.se
Abstract:
Antibodies can act like adjuvants. They can potently enhance the antibody response, and in the case of IgG and IgE also the T cell response, to the very antigen they are specific for. In this review we will discuss the recent advances made in our understanding of the underlying mechanisms of antibody-mediated feedback enhancement. The immuno-stimulatory properties of IgM, IgG1, IgG2a, IgG2b, IgG3 and IgE will be reviewed in relationship to the complement system and Fc receptors and the physiological relevance will be discussed.
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