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Related Experiment Videos

[Ifosfamide induced encephalopathy: 15 observations].

C Dufour1, J Grill, P Sabouraud

  • 1Service de pédiatrie A, hôpital américain, CHU de Reims, 49, rue Cognacq-Jay, 51100 Reims, France. cdufour@chu-reims.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|December 21, 2005
PubMed
Summary
This summary is machine-generated.

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Ifosfamide can cause encephalopathy in children treated for cancer. Early recognition and treatment with Methylene Blue can help manage this side effect, allowing for continued ifosfamide therapy.

Area of Science:

  • Oncology
  • Neuroscience
  • Pharmacology

Context:

  • Ifosfamide is a crucial chemotherapeutic agent for various pediatric cancers.
  • Ifosfamide-induced encephalopathy is a significant, potentially dose-limiting toxicity.
  • The incidence of ifosfamide encephalopathy can be as high as 30% in pediatric patients.

Purpose:

  • To report on 15 cases of ifosfamide-induced encephalopathy in children treated for solid tumors.
  • To review the clinical presentation, management, and outcomes of this neurotoxicity.
  • To propose recommendations for managing ifosfamide encephalopathy.

Summary:

  • Fifteen pediatric patients with solid tumors developed neurotoxicity ranging from drowsiness to coma and convulsions following ifosfamide treatment.
  • Neurotoxicity was generally reversible within 3-5 days after ifosfamide discontinuation.

Related Experiment Videos

  • Methylene Blue administration showed variable efficacy, but prophylactic use during re-challenge with ifosfamide appeared effective.

    • Impact:

    • This study highlights the importance of prompt recognition and management of ifosfamide-induced encephalopathy.
    • Recommendations for Methylene Blue treatment and prophylactic use can guide clinical practice.
    • Successful re-challenge with ifosfamide under prophylactic Methylene Blue suggests that this toxicity may not always preclude further treatment.