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Does Helicobacter pylori have a pathogenic role in bronchiectasis?
J Angrill1, N Sánchez, C Agustí
1Servei de Pneumologia, Hospital Clínic, Institut d'lnvestigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Villarroel 170, 08036 Barcelona, Spain. jangrill@clinic.ub.es
Aim:
To investigate the presence of Helicobacter pylori (H. pylori) in bronchial biopsies of patients with bronchiectasis, by histochemical and immunochemical staining.
Setting:
800-bed tertiary university hospital.
Methods:
Observational study.
Patients:
forty-six patients with bronchiectasis in a stable clinical condition and 8 control patients.
Interventions:
Serum samples determination of IgG levels for H. pylori by ELISA. Immunostaining with an anti-H. pylori antibody (NCL-HPp, Novocastra) of bronchial mucosa obtained by fiberoptic bronchoscopy from both patients with bronchiectasis and controls.
Results:
Twenty-one out of 46 patients with bronchiectasis (46%) had positive serology for H. pylori. We obtained 40 bronchial biopsies in patients with bronchiectasis and 8 bronchial biopsies in control patients. No evidence of H. pylori was obtained in the bronchial samples of both patients and controls.
Conclusions:
The results of our study could not demonstrate the presence of H. pylori in bronchial specimens from patients with bronchiectasis.
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