Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatitis delta virus.

John M Taylor1

  • 1Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111-2497, USA. john.taylor@fccc.edu

Virology
|December 21, 2005
PubMed
Summary
This summary is machine-generated.

Hepatitis delta virus (HDV) requires hepatitis B virus (HBV) for its envelope proteins, but HDV RNA replication is host-cell dependent. Research explores HDV replication and future directions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Should We Keep or Remove Outliers?

The Journal of nursing education·2026
Same author

Check for Outliers.

The Journal of nursing education·2026
Same author

Sub-lethal effects of natural cyanobacterial blooms on fish: Enzymatic activity and swimming performance in Gasterosteus aculeatus.

Harmful algae·2025
Same author

Questionable Research Practices: HARKing.

The Journal of nursing education·2025
Same author

Questionable Research Practices: Cherry Picking.

The Journal of nursing education·2025
Same author

Questionable Research Practices: <i>p</i>-Hacking.

The Journal of nursing education·2025
Same journal

Viral diversity in predatory insects used for biological control: Insights from a multi-country meta-viromic analysis.

Virology·2026
Same journal

Unveiling the hidden virome of Sclerotinia sclerotiorum: New tools and discoveries in mycovirus detection.

Virology·2026
Same journal

ASFV pDP238L negatively regulates type I interferon production via inhibiting the methylation of TBK1.

Virology·2026
Same journal

Divergent poxvirus identified in a non-native black rat from Madagascar.

Virology·2026
Same journal

Genomic and functional characterization of Bacillus phage BCE1 targeting a key gut bacterium in Aedes albopictus larvae.

Virology·2026
Same journal

Viral etiology of orogenital papillomatosis and squamous cell carcinoma in bottlenose dolphins in the southeastern United States.

Virology·2026
See all related articles

Area of Science:

  • Virology
  • Molecular Biology
  • Hepatology

Background:

  • Hepatitis delta virus (HDV) is a unique sub-viral agent that relies on hepatitis B virus (HBV) for essential functions.
  • HDV requires HBV envelope proteins for viral particle assembly, attachment, and entry into host cells.
  • Despite HBV dependence for some steps, HDV RNA replication is largely independent of HBV.

Purpose of the Study:

  • To provide an overview of Hepatitis delta virus (HDV) and its replication mechanisms.
  • To highlight major unresolved questions in HDV research.
  • To offer perspectives and speculations on the future of HDV studies.

Main Methods:

  • Review of existing literature on HDV and HBV interactions.
  • Analysis of HDV genome replication processes.

Related Experiment Videos

  • Identification of host cell factors involved in HDV replication.

    • Main Results:

    • HDV utilizes HBV surface proteins for its life cycle, including assembly and entry.
    • HDV genome replication is independent of HBV and relies on host cell machinery.
    • HDV replication yields two forms of delta antigens (long and small).

    Conclusions:

    • HDV represents a distinct viral entity with specific dependencies and independent replication strategies.
    • Understanding host-cell involvement in HDV replication is crucial.
    • Further research is needed to address outstanding questions in HDV pathogenesis and treatment.