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Adiponectin and arterial stiffness.

Azra Mahmud1, John Feely

  • 1Department of Therapeutics and Hypertension Clinic, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland.

American Journal of Hypertension
|December 21, 2005
PubMed
Summary
This summary is machine-generated.

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Adiponectin levels show a varied link with arterial stiffness in hypertension. While adiponectin predicts aortic pulse wave velocity (PWV), it does not predict augmentation index (AIx), suggesting complex cardiovascular associations.

Area of Science:

  • Cardiovascular physiology
  • Endocrinology
  • Hypertension research

Background:

  • Adiponectin, an anti-inflammatory adipocytokine, is decreased in conditions like hypertension, diabetes, and coronary artery disease (CAD).
  • Arterial stiffness, measured by aortic pulse wave velocity (PWV) or augmentation index (AIx), is a significant predictor of cardiovascular mortality.
  • The relationship between adiponectin and arterial stiffness in essential hypertension requires further elucidation.

Purpose of the Study:

  • To investigate the association between plasma adiponectin levels and markers of arterial stiffness in patients with essential hypertension.
  • To determine if adiponectin is an independent predictor of arterial stiffness parameters like PWV and AIx.

Main Methods:

  • Seventy-six untreated patients with essential hypertension underwent measurements of blood pressure, carotid-femoral PWV, AIx, plasma adiponectin, and C-reactive protein (CRP).

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  • Data were analyzed using univariate and multiple logistic regression analyses.
  • Standard ELISA techniques were employed for plasma adiponectin and CRP measurements after an overnight fast.

    • Main Results:

    • A significant positive correlation was observed between adiponectin and AIx (r = 0.33, P < .005), and HDL-cholesterol.
    • Conversely, adiponectin showed significant negative relationships with PWV (r = -0.24, P < .05), transit time, and pulse pressure amplification.
    • In regression models, adiponectin independently predicted PWV but not AIx, which was influenced by heart rate, height, mean arterial pressure, age, and gender.

    Conclusions:

    • Adiponectin exhibits a divergent relationship with arterial stiffness: negative for PWV and positive for wave reflection (AIx).
    • Anthropometric factors like height, weight, and heart rate may modulate the adiponectin-AIx relationship.
    • Adiponectin is identified as an independent predictor of aortic PWV, but not AIx, in essential hypertension.