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Updated: Aug 3, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
04:41

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

Published on: July 15, 2010

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo

John R Cirrito1, Kelvin A Yamada, Mary Beth Finn

  • 1Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

Neuron
|December 21, 2005
PubMed
Summary

Brain synaptic activity dynamically influences amyloid-beta (Abeta) levels, impacting Alzheimer's disease progression. This suggests new therapeutic targets for Abeta deposition and neurodegeneration.

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