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Updated: Aug 14, 2026
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
High-resolution computed tomography findings of lung cancer associated with idiopathic pulmonary fibrosis
Kazuma Kishi1, Sakae Homma, Atsuko Kurosaki
1Department of Clinical Oncology, Toranomon Hospital, Tokyo, Japan. kazumak@toranomon.gr.jp
Objective:
The purpose of this study was to evaluate high-resolution computed tomography (HRCT) findings of lung cancer associated with idiopathic pulmonary fibrosis (IPF).
Methods:
Thirty patients with lung cancer who had preceding IPF and were receiving regular follow-up between 1993 and 2002 were examined. Medical records, radiographs (including HRCT scans), and histologic slides were reviewed.
Results:
In 28 of the 30 patients, the most common HRCT pattern of lung cancer was a nodular lesion with soft tissue attenuation. Nodule margins were well defined in 23 lesions (82.1%), associated with lobulation in 24 (85.7%), or characterized by spiculation in 14 (50%). Air bronchogram was observed in 16 lesions (57.1%). All nodules were located in the peripheral area of fibrotic lesions. Squamous cell carcinoma and adenocarcinoma were the most frequent histologic types.
Conclusions:
The typical HRCT findings of lung cancer were well-defined nodular lesions with lobulation in peripheral areas of the lung.
