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Autonomic dysfunction in systemic lupus erythematosus.

Shalimar1, Rohini Handa, Kishore Kumar Deepak

  • 1Department of Medicine, All India Institute of Medical Sciences, 110029 New Delhi, India.

Rheumatology International
|December 21, 2005
PubMed
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Autonomic dysfunction is common in systemic lupus erythematosus (SLE), affecting nearly 40% of patients. This dysfunction can occur independently of peripheral neuropathy and lacks clear clinical predictors, requiring further research.

Area of Science:

  • Rheumatology
  • Neurology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
  • Autonomic nervous system (ANS) dysfunction can affect various organ systems in SLE patients.
  • Understanding the prevalence and patterns of ANS dysfunction is crucial for comprehensive SLE management.

Purpose of the Study:

  • To investigate the frequency and characteristics of autonomic dysfunction in patients with SLE.
  • To compare autonomic function between SLE patients and healthy controls.
  • To explore potential correlations between autonomic dysfunction and clinical parameters in SLE.

Main Methods:

  • Prospective study involving 51 SLE patients and 30 age- and sex-matched healthy controls.

Related Experiment Videos

  • Utilized a standard battery of noninvasive tests to assess autonomic nervous system function.
  • Evaluated autonomic symptoms and laboratory findings indicative of dysfunction.

    • Main Results:

    • Autonomic symptoms were reported by 37% of SLE patients.
    • Incipient autonomic dysfunction was detected in 18% of SLE patients versus 3% of controls.
    • Atypical autonomic involvement was observed in 21% of SLE patients compared to 20% of controls.
    • No significant correlation was found between autonomic dysfunction and disease duration, activity, damage, organ involvement, or peripheral neuropathy.
    • Autonomic neuropathy can be present in SLE independently of peripheral neuropathy.

    Conclusions:

    • Autonomic dysfunction is a frequent, yet often subclinical, complication in SLE patients.
    • The absence of specific clinical predictors highlights the need for objective testing.
    • Autonomic neuropathy in SLE may occur without peripheral neuropathy.
    • Further longitudinal studies are warranted to elucidate the clinical significance of laboratory-detected autonomic dysfunction in SLE.