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Fluoromorphic substrates for fatty acid metabolism: highly sensitive probes for mammalian medium-chain acyl-CoA

Mary K Froemming1, Dalibor Sames

  • 1Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027, USA.

Angewandte Chemie (International Ed. in English)
|December 21, 2005
PubMed
Abstract

No abstract available in PubMed .

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Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...