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Methotrexate-induced acute lung injury in a patient with rheumatoid arthritis
K Taniguchi1, Y Usui, T Matsuda
1Division of Rheumatic Diseases, Tokyo Metropolitan Bokutoh Hospital, Koutohbashi, Sumida-ku, Tokyo, Japan. kevmed1@excite.co.jp
Abstract:
Methotrexate (MTX)-induced acute lung injury developed in a female patient with rheumatoid arthritis. She was successfully treated with high-dose glucocorticoid therapy. During her hospital stay, the serum concentration of surfactant protein (SP)-D, which was markedly elevated on admission, was finally normalized and the disease resolved. However, the serum concentration of Klebs von den Lungen (KL)-6 remained high. Although the mechanisms of lung injury by MTX have not been well defined, serial measurements of serum SPD might be useful for the clinical evaluation of drug-induced acute lung injury.
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