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Updated: Aug 14, 2026

Operant Sensation Seeking in the Mouse
Published on: November 10, 2010
Sensation seeking and the aversive motivational system
Shmuel Lissek1, Johanna M P Baas, Daniel S Pine
1National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, MD 20892-2670, USA. lisseks@intra.nimh.nih.gov
Abstract:
Sensation seeking (SS) has traditionally been viewed as a phenomenon of the appetitive motivational system. The limited SS research exploring contributions from the aversive motivational system reveals greater anxious reactivity to dangerous activities among low sensation seekers. The present study extends this line of work by comparing levels of fear and anxiety during anticipation of predictable and unpredictable aversive stimuli across high- and low-SS groups. Low sensation seekers displayed greater fear-potentiated startle (FPS) to predictable aversive stimuli, and only those low on SS showed FPS and skin conductance response effects during experimental contexts in which aversive stimuli were delivered unpredictably. Findings implicate enhanced apprehensive anticipation among those low on SS as a potential deterrent for their participation in intense and threatening stimulus events.
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