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Unraveling the mystery of gammadelta T cell recognizing lipid A

Yongchun Cui1, Lianxian Cui, Wei He

  • 1Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.

Cellular & Molecular Immunology
|December 22, 2005
PubMed

Traditionally, the materials which are regarded as antigens recognized by gammadelta T lymphocytes are protein and carbohydrate, not nucleic acid or lipid. Recently, it has been demonstrated that gammadelta T cells can recognize lipid A and directly induce immune responses that involve CD1 (cluster of differentiation type 1) family and Toll like receptors (TLRs). This is a review about the interacting-mechanism, immunological effect and clinical application of them.

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