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Coapsys mitral annuloplasty for chronic functional ischemic mitral regurgitation: 1-year results

Yugal K Mishra1, Sanjay Mittal, Pravesh Jaguri

  • 1Department of Cardiac Surgery, Escorts Heart Institute and Research Centre, New Delhi, India. dryugal@yahoo.com

The Annals of Thoracic Surgery
|December 22, 2005
PubMed

Insights

The Coapsys annuloplasty system effectively reduces functional ischemic mitral regurgitation (MR) in patients undergoing coronary artery bypass grafting (CABG). This innovative device shows sustained safety and efficacy at one year, improving patient outcomes.

Area of Science:

  • Cardiovascular Surgery
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Untreated functional ischemic mitral regurgitation (MR) significantly reduces survival in patients undergoing coronary artery bypass grafting (CABG).
  • Traditional mitral valve repair or replacement increases mortality and morbidity compared to CABG alone.
  • The Myocor Coapsys annuloplasty system offers a potential solution by reducing MR on a beating heart without requiring atriotomy.

Purpose of the Study:

  • To evaluate the safety and efficacy of the Myocor Coapsys annuloplasty system in reducing functional ischemic MR.
  • To assess the impact of the Coapsys system on clinical outcomes and echocardiographic parameters at 1-year follow-up.

Main Methods:

  • A prospective study included patients with preoperative grade 2 or greater ischemic functional MR referred for CABG.
  • The Coapsys system, comprising epicardial pads and a flexible chord, was implanted without cardiopulmonary bypass.
  • Serial clinical and echocardiographic data were collected for 1 year post-implantation.

Main Results:

  • Significant reduction in MR grade (2.9 to 1.1), MR jet area (7.4 to 3.0 cm²), and NYHA class (2.5 to 1.2) was observed at 1 year (p < 0.05).
  • No deaths, device failures, reemergence of severe MR, heart failure readmissions, or valve reoperations occurred during follow-up.
  • Mean patient age was 58.1 years with a mean ejection fraction of 38.5%.

Conclusions:

  • The Coapsys annuloplasty system demonstrates effectiveness in reducing functional ischemic MR and improving NYHA class.
  • Initial data suggest the device is safe, with sustained benefits observed at the 1-year follow-up.
  • The Coapsys system presents a promising approach for managing ischemic MR in CABG patients.
Abstract

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