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Regulation of matrix metalloproteinase (MMP) gene expression by protein kinases

Paul M Reuben1, Herman S Cheung

  • 1Research Service and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Miami, Florida 33125, USA.

Frontiers in Bioscience : a Journal and Virtual Library
|December 22, 2005
PubMed

Insights

Matrix metalloproteinases (MMPs), crucial for tissue remodeling, are regulated by protein kinases. This review details how protein kinases control MMP gene expression and signaling pathways, impacting human diseases.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matrix components.
  • MMPs are vital for tissue turnover and remodeling in physiological and pathological states.
  • Dysregulated MMP expression contributes to various human diseases.

Purpose of the Study:

  • To review the regulation of MMPs by protein kinases.
  • To elucidate the role of protein kinases in MMP gene expression and signaling pathways.

Main Methods:

  • Literature review of studies on MMPs and protein kinase regulation.
  • Analysis of signaling pathways involved in MMP synthesis and degradation control.

Main Results:

  • Protein kinases tightly control MMP synthesis and breakdown, maintaining extracellular matrix equilibrium.
  • MMPs are induced by various agents, and their uncontrolled expression is linked to disease pathogenesis.
  • Specific MMPs are responsible for matrix degradation and remodeling.

Conclusions:

  • Protein kinase regulation is critical for controlling MMP activity.
  • Understanding these regulatory mechanisms is essential for developing therapeutic strategies against MMP-related diseases.

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