Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microarray tools for deciphering complex diseases.

Ruty Mehrian Shai1

  • 1University of Southern California, Institute for Genetic Medicine, CSC/IGM 263, Los Angeles, California 90033, USA. mehrian@usc.edu

Frontiers in Bioscience : a Journal and Virtual Library
|December 22, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease.

PloS one·2009
Same author

Pharmacogenomics of brain cancer and personalized medicine in malignant gliomas.

Future oncology (London, England)·2008
Same author

Comparisons of PCR-based genome amplification systems using CpG island microarrays.

Human mutation·2006
Same author

Robustness of gene expression profiling in glioma specimen samplings and derived cell lines.

Brain research. Molecular brain research·2005
Same journal

The CD44 protein family: roles in embryogenesis and tumor progression.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Four varieties of voltage-gated proton channels.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Lurie's tubercle-count method to test TB vaccine efficacy in rabbits.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Optical spectroscopy of breast biopsies and human breast cancer xenografts in nude mice.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

The colostrum-deprived, artificially-reared, neonatal pig as a model animal for studying rotavirus gastroenteritis.

Frontiers in bioscience : a journal and virtual library·2017
Same journal

Action of polypeptide growth factors in colon cancer; development of new therapeutic approaches.

Frontiers in bioscience : a journal and virtual library·2017
See all related articles

Complex diseases require integrated analysis of multiple factors beyond genetics. Microarray technology allows simultaneous, genome-wide interrogation of DNA, RNA, and protein, paving the way for precise diagnostics and therapeutics.

Area of Science:

  • Genomics
  • Molecular Biology
  • Systems Biology

Background:

  • Individual genetic findings alone are insufficient to explain complex disease etiology or pathogenesis.
  • Current approaches lack comprehensive data for effective drug development in most population disease cases.
  • Multilevel etiologic factors, including environmental, epigenetic, and molecular alterations, underlie human diseases.

Purpose of the Study:

  • To highlight the limitations of single-factor genetic analysis in complex diseases.
  • To introduce integrative evaluation of multiple etiologic factors for a comprehensive understanding of disease.
  • To present microarray technology as a tool for simultaneous, genome-wide interrogation of disease-related factors.

Main Methods:

  • Utilizing microarrays for simultaneous, genome-wide analysis of DNA, RNA, and protein content.

Related Experiment Videos

  • Interrogating individualized factors in single cells or tissues.
  • Combining data from various microarray studies.

    • Main Results:

    • Microarray technology enables expeditious interrogation of multiple disease-related factors.
    • Integrated analysis of diverse molecular data offers a comprehensive view of complex diseases.
    • This approach holds promise for reducing costs and timelines in drug discovery and improvement.

    Conclusions:

    • Integrative evaluation of multilevel etiologic factors is crucial for understanding complex diseases.
    • Microarray studies offer a powerful approach for comprehensive disease insight and precise diagnostics.
    • Future utilization of microarray data will facilitate precise prognosis and therapy development.