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Related Experiment Videos

Apoptosis Gene Information System--AGIS.

Kishore R Sakharkar1, Marie V Clement, Vincent T K Chow

  • 1Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Frontiers in Bioscience : a Journal and Virtual Library
|December 22, 2005
PubMed
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Scientists created the Apoptosis Gene Information System (AGIS) to catalog over 2400 genes involved in programmed cell death (apoptosis) across 350 organisms. This resource will be updated regularly to include new discoveries in apoptosis research.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Apoptosis, or programmed cell death, is crucial in development, immunity, and disease, particularly cancer.
  • Understanding genes involved in apoptosis is vital for biological and medical research, including oncology.
  • A centralized, comprehensive database for apoptosis-related genes is needed.

Purpose of the Study:

  • To introduce the Apoptosis Gene Information System (AGIS), a novel resource for apoptosis gene data.
  • To provide a curated collection of genes directly or indirectly involved in apoptotic pathways.
  • To facilitate research by offering data across a wide range of organisms.

Main Methods:

  • Data compilation from scientific literature and databases.
  • System organization based on a 'one-gene, one-record' principle.

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  • Development of a web-accessible platform for data retrieval.

    • Main Results:

    • AGIS contains information on over 2400 genes linked to apoptosis.
    • The system covers more than 350 different organisms.
    • Data is structured for easy access and analysis.

    Conclusions:

    • AGIS serves as a valuable, up-to-date resource for researchers studying apoptosis.
    • The system supports interdisciplinary research in biology, medicine, and oncology.
    • Regular updates ensure AGIS remains a relevant and comprehensive tool for the scientific community.