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Related Experiment Videos

Testosterone and estradiol among older men.

Eric Orwoll1, Lori C Lambert, Lynn M Marshall

  • 1CR113, Oregon Health & Science University, 3181 SW Sam Jackson Park, Portland, Oregon 97239, USA. orwoll@ohsu.edu

The Journal of Clinical Endocrinology and Metabolism
|December 22, 2005
PubMed
Summary

Sex steroid levels, including testosterone and estradiol, decline with age in older men. However, significant individual variation exists, suggesting complex relationships with aging. Keywords: testosterone, estradiol, aging men, hormone levels.

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Area of Science:

  • Endocrinology
  • Gerontology
  • Men's Health

Background:

  • Sex steroid levels, including testosterone and estradiol, naturally decrease with age in men.
  • This age-related decline may impact various clinical outcomes in elderly men.
  • Limited data exists on the distribution and correlates of these hormone levels in older male populations.

Purpose of the Study:

  • To evaluate sex steroid hormone levels in a large cohort of elderly men.
  • To assess the distribution and variability of testosterone and estradiol concentrations.
  • To identify factors associated with sex steroid levels in aging men.

Main Methods:

  • Cross-sectional cohort study design.
  • Analysis of a subsample of 2623 participants from the Osteoporotic Fractures in Men Study (MrOS).

Related Experiment Videos

  • Measurement of total and free testosterone, free estradiol, and sex hormone-binding globulin (SHBG).

    • Main Results:

    • Inverse association observed between age and free testosterone/estradiol levels.
    • Significant variation in hormone levels was noted across all ages.
    • Lower free testosterone linked to higher BMI, lower SHBG, poorer health, and Asian race.
    • Lower free estradiol associated with lower BMI and higher SHBG.

    Conclusions:

    • This study represents the largest cohort of older men with available sex steroid data.
    • Confirms age-related decline in testosterone and estradiol, including free fractions, in older men.
    • Highlights substantial individual variability, indicating complex relationships between sex steroids and aging outcomes.