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New World monkey Aotus nancymae as a model for Campylobacter jejuni infection and immunity
Franca R Jones1, Shahida Baqar, Alfonso Gozalo
1Naval Medical Research Center, Biological Defense Research Directorate, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA. jonesf@nmrc.navy.mil
Infection and Immunity
|December 22, 2005
Abstract:
Three groups of six monkeys (Aotus nancymae) each were inoculated intragastrically with increasing doses of Campylobacter jejuni. Infection resulted in fecal colonization (100% of monkeys), dose-related diarrhea, and robust immune responses. Colonization duration and diarrhea rate were reduced upon secondary challenge. A. nancymae may be useful for studying anti-Campylobacter vaccine efficacy.
