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Catch bonds: physical models, structural bases, biological function and rheological relevance.

Cheng Zhu1, Jizhong Lou, Rodger P McEver

  • 1Coulter Department of Biomedical Engineering, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA. cheng.zhu@me.gatech.edu

Biorheology
|December 22, 2005
PubMed
Summary

Force can paradoxically prolong molecular bond lifetimes, a phenomenon called catch bonds. This review covers recent evidence, theoretical models, and implications of catch bonds in biological systems.

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Area of Science:

  • Biophysics
  • Molecular Biology
  • Rheology

Background:

  • Force can accelerate the dissociation of macromolecular complexes, shortening their lifetimes.
  • However, some molecular bonds exhibit catch bonds, where force prolongs their lifetime, contrary to typical slip bond behavior.

Purpose of the Study:

  • To review recent findings on catch bonds, particularly in the selectin system.
  • To discuss theoretical models, structural bases, and biorheological relevance of catch bonds.

Main Methods:

  • Review of recently published experimental data demonstrating catch bonds.
  • Analysis of theoretical models explaining catch bond mechanisms.
  • Examination of structural and functional implications in biological systems.

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Main Results:

  • Catch bonds have been experimentally observed in the selectin system.
  • Evidence suggests catch bonds may exist in other biological systems.
  • Theoretical models and structural bases for catch bonds are being developed.

Conclusions:

  • Catch bonds represent a significant departure from conventional force-dependent bond dynamics.
  • Understanding catch bonds is crucial for comprehending flow-enhanced adhesion and biorheological processes.
  • Further research is needed to fully elucidate the prevalence and mechanisms of catch bonds.