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Updated: Aug 14, 2026
08:46
Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms
Published on: December 9, 2015
Aspirin resistance and its implications in clinical practice
John Eikelboom1, Mark Feldman, Shamir R Mehta
1McMaster University, Hamilton, Ontario, Canada. eikelbj@mcmaster.ca
Medgenmed : Medscape General Medicine
|December 22, 2005
Summary
Some patients may not fully benefit from aspirin therapy due to aspirin resistance. Experts recommend continuing prescribed aspirin for cardiovascular risk reduction until its clinical significance is better understood.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Hematology
Background:
- Growing evidence suggests aspirin resistance may limit therapeutic efficacy in some patients.
- Aspirin's antiplatelet effects are crucial for preventing cardiovascular events.
Framework:
- An international expert roundtable convened to discuss aspirin resistance.
- Key topics included definitions, mechanisms, and diagnostic tests for aspirin resistance.
Implementation:
- Current platelet function tests for aspirin resistance were reviewed.
- The clinical utility of these tests remains under investigation.
Implications:
- Physicians should maintain current low-dose aspirin prescriptions for high-risk cardiovascular patients.
- Patients on aspirin therapy should adhere to prescribed regimens.
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