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Cellular ITAM-containing proteins are oncoproteins in nonhematopoietic cells

S M Grande1, E Katz, J E Crowley

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Oncogene
|December 22, 2005
PubMed
Summary

Non-viral ITAM proteins can transform cells, causing loss of anchorage dependence and epithelial to mesenchymal transition. This transformation is reversed by mutations in ITAMs or Syk kinase inhibition, highlighting ITAMs as potent oncoproteins.

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