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Induction of RANTES and CCR5 through NF-kappaB activation via MAPK pathway in aged rat gingival tissues
Hyung Keun Kim1, Hae Ryoun Park, Kyoung Hee Sul
1Research Institute of Genetic Engineering, Pusan National University, 609-735, Busan, Korea.
Abstract:
Chemokine and chemokine receptor expression in gingival tissues plays a central role in periodontal disease during aging. In the present study, we explored the modulation of chemokines and chemokine receptors expression in aging rat gingival tissues. In the 24-month-old (Old) rat gingival tissues, RANTES and CCR5 mRNA and protein levels were 2-4 fold increased over those of the 6-month-old (Young) rats. The Old rats had considerable enhancement of all three of the studied MAPK activities: extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK. These results suggest that age-related increases in RANTES and CCR5 expression are associated with increased IkappaBalpha, nuclear NF-kappaB, and MAPK activity in gingival tissues.
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