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Ghrelin and GHS on cardiovascular applications/functions

J Isgaard1, I Johansson

  • 1Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska Academy, University of Göteborg, Sweden. jorgen.isgaard@medic.gu.se

Journal of Endocrinological Investigation
|December 24, 2005
PubMed

Insights

Growth hormone secretagogues (GHS) and ghrelin show potential cardiovascular benefits, including reduced peripheral resistance and cardioprotection. Further research is warranted to explore their therapeutic role in cardiovascular diseases.

Area of Science:

  • Endocrinology
  • Cardiovascular Physiology

Background:

  • Growth hormone secretagogues (GHS) were initially known for growth hormone release.
  • Emerging evidence suggests GHS and ghrelin impact the cardiovascular system.

Purpose of the Study:

  • To review the cardiovascular effects of GHS and ghrelin.
  • To assess the potential therapeutic applications of GHS and ghrelin in cardiovascular disease.

Main Methods:

  • Literature review of studies on GHS and ghrelin cardiovascular effects.
  • Analysis of in vivo and in vitro experimental data.

Main Results:

  • Reported effects include decreased peripheral resistance.
  • Potential improvements in cardiac contractility observed.
  • Cardioprotective effects demonstrated in various models.

Conclusions:

  • GHS and ghrelin exhibit significant cardiovascular effects.
  • These findings suggest a potential role for GHS and ghrelin in treating cardiovascular conditions.
  • Further investigation into GHS and ghrelin for cardiovascular disease therapy is recommended.

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