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Melatonin hormone profile in infertile males
Hosni Awad1, Fawzy Halawa, Taymour Mostafa
1Andrology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
International Journal of Andrology
|December 24, 2005
Summary
Melatonin, a key hormone, shows lower levels in infertile men, particularly impacting sperm motility. These findings suggest melatonin
Area of Science:
- Reproductive Endocrinology
- Hormone Research
- Male Infertility Studies
Background:
- Melatonin, a pineal gland hormone, has a debated role in male reproduction.
- Understanding melatonin's influence on male fertility is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate serum and seminal plasma melatonin levels in various male infertility groups.
- To correlate melatonin levels with semen parameters and reproductive hormones (FSH, T, PRL).
Main Methods:
- Studied 120 men across six groups: fertile, oligoasthenozoospermia (OA), OA with leucocytospermia, OA with varicocele, and two non-obstructive azoospermia (NOA) subgroups.
- Performed semen analysis and measured melatonin, FSH, testosterone, and prolactin levels.
Main Results:
- Serum and seminal melatonin were significantly lower in all infertile groups compared to fertile men.
- Lowest melatonin levels were observed in OA with leucocytospermia.
- Melatonin levels correlated positively with sperm motility and serum prolactin.
Conclusions:
- Melatonin may play a role in modulating the male reproductive neuroendocrine axis.
- Reduced seminal melatonin is linked to decreased sperm motility, leucocytospermia, varicocele, and NOA.