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Related Experiment Videos

Seminal tissue factor revisited.

B Lwaleed1, C Jackson, R Greenfield

  • 1Department of Urology, Southampton University Hospitals NHS Trust, Southampton, UK.

International Journal of Andrology
|December 24, 2005
PubMed
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Seminal tissue factor (TF) is present in high concentrations in semen, potentially playing a role in coagulation. Lower TF levels correlate with improved male fertility parameters.

Area of Science:

  • Reproductive Biology
  • Hemostasis
  • Andrology

Background:

  • Previous studies suggested seminal tissue factor (TF) might not be involved in seminal coagulum formation due to a reported lack of factor X.
  • Recent discoveries of hemostatic factors in semen necessitate a re-evaluation of TF's role.

Purpose of the Study:

  • To investigate the presence and concentration of functional and antigenic TF in semen.
  • To correlate seminal TF levels with fertility parameters and sperm characteristics.

Main Methods:

  • Semen specimens were collected from sub-fertile, normally fertile, semen donors, and vasectomized subjects.
  • Semen was fractionated into sperm, prostasome-rich fraction, and seminal plasma.
  • Functional and antigenic TF levels were quantified and analyzed in relation to fertility parameters.

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Main Results:

  • Semen contains high concentrations of both functional and antigenic TF, primarily in seminal plasma and prostasomal fractions.
  • TF antigen levels were significantly higher in vasectomized subjects compared to fertile groups.
  • Seminal TF antigen levels correlated with sperm agglutination and abnormal morphology, and were elevated in subjects with anti-sperm antibodies.

Conclusions:

  • Semen harbors substantial amounts of functional and antigenic TF, suggesting a potential pro-coagulant role.
  • The presence of a full complement of clotting factors in semen supports TF's involvement in coagulation.
  • Reduced seminal TF levels are associated with improved male fertility parameters.