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Related Experiment Videos

WebArray: an online platform for microarray data analysis.

Xiaoqin Xia1, Michael McClelland, Yipeng Wang

  • 1Genomic Core Facility, Sidney Kimmel Cancer Center, San Diego, CA 92121, USA. xxia@skcc.org

BMC Bioinformatics
|December 24, 2005
PubMed
Summary
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WebArray is a free online platform that simplifies complex microarray data analysis for biologists. It provides user-friendly access to powerful tools like limma and affy, making advanced analysis accessible without extensive technical expertise.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Microarray analysis tools often require advanced statistical and computational skills.
  • Commercial software offers user-friendliness but at a high cost.
  • Bench biologists face challenges in accessing and implementing sophisticated microarray analysis algorithms.

Purpose of the Study:

  • To develop an accessible, open-platform solution for microarray data analysis.
  • To empower bench biologists with advanced analytical capabilities.
  • To facilitate the exploration of single/dual color microarray experimental data.

Main Methods:

  • Development of the WebArray online platform.
  • Integration of Bioconductor packages (limma, affy).

Related Experiment Videos

  • Implementation of methods including SPLOSH, PCA-assisted normalization, and genome mapping.
  • Main Results:

    • WebArray provides a user-friendly interface for complex microarray analysis.
    • Key functions include quality weighting, background correction, normalization, and statistical analysis (FDR estimation).
    • The platform supports chromosomal mapping for genome comparison.

    Conclusions:

    • WebArray offers a convenient and free platform for accessing cutting-edge microarray analysis tools.
    • The platform is accessible to biologists without extensive programming or statistical knowledge.
    • WebArray is freely available online and runs on a Linux server.