Related Experiment Video
Updated: Aug 14, 2026
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
[Colorectal carcinoma in the young. Prognostic factors]
M Miccini1, G Mazzoni, D Cassini
1Dipartimento de Chirurgia Pietro Valdoni, Università degli Studi La Sapienza di Roma.
Il Giornale Di Chirurgia
|December 24, 2005
Summary
Colorectal cancer in young adults under forty presents unique challenges. Surgical treatment yielded no perioperative mortality but showed a 33% five-year survival rate, highlighting the need for further research.
Area of Science:
- Oncology
- Surgical Oncology
- Gastroenterology
Context:
- Colorectal carcinoma is a prevalent malignancy, typically affecting individuals in their sixth decade.
- A small percentage (2-8%) of colorectal tumors occur in patients younger than 40 years.
- Early-onset colorectal cancer presents distinct clinical and pathological characteristics.
Purpose:
- To analyze the outcomes of surgical interventions for colorectal cancer in patients under the age of forty.
- To evaluate the short-term and long-term results of treating early-onset colorectal cancer.
Summary:
- A study included 46 patients under forty with colorectal cancer who underwent surgery between 1987 and 2002.
- No perioperative mortality was observed; 20% of patients experienced complications.
- The actuarial five-year survival rate was 33%, with a mean overall survival of 53 months.
Impact:
- Identified tumor grade, Dukes' stage, nodal status, and symptom duration as significant prognostic factors in young patients.
- Findings underscore the aggressive nature of early-onset colorectal cancer and inform treatment strategies.
- Emphasizes the importance of considering age as a factor in colorectal cancer prognosis and management.
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