Related Experiment Video
Updated: Aug 14, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
[Cardiac cephalgia: an underdiagnosed condition? ]
Jesús Gutiérrez Morlote1, José M Fernández García, Juan J Timiraos Fernández
1Servicio de Cardiología, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Insights
Cardiac cephalgia, a type of headache from myocardial ischemia, is a newly recognized condition. Suspect cardiac cephalgia in ischemic heart patients with new headaches that improve with nitrates, even without chest pain.
Area of Science:
- Cardiology
- Neurology
Background:
- Cardiac cephalgia, a headache linked to myocardial ischemia, is a recently identified clinical entity.
- Diagnosis in patients with known ischemic heart disease requires severe headache, nausea, exercise exacerbation, and relief with nitrates.
Observation:
- Two cases of cardiac cephalgia are presented where headache was the sole presenting symptom of coronary ischemia.
- Headache occurred both at rest and during exertion, resolving only after nitrate administration, delaying diagnosis.
Findings:
- Headache as the primary or only symptom of myocardial ischemia can mimic other headache disorders.
- The diagnostic criteria for cardiac cephalgia involve specific headache characteristics and response to nitrates.
Implications:
- Clinicians should consider cardiac cephalgia in patients with ischemic cardiomyopathy presenting with new-onset headaches, particularly if responsive to nitrates.
- Accurate differential diagnosis from conditions like migraine is essential to guide appropriate treatment and avoid vasoconstrictive therapies.
Abstract:
Cardiac cephalgia, or headache occurring as manifestation of myocardial ischemia, has only recently been recognized as a distinct entity. In patients with known ischemic cardiopathy, its diagnosis depends on the presence of severe headache that is accompanied by nausea, worsened by physical exercise, and only ceases with nitrate administration. We report on two patients who met diagnostic criteria for this entity. In both, headache was the only symptom of coronary ischemia, and delayed its diagnosis. Headache occurred both at rest and during exertion, and resolved only after the administration of nitrates. Cardiac cephalgia should be suspected in patients with a history of ischemic cardiopathy who present with de novo headache, even when thoracic pain is absent, especially if the headache improves with nitrates. Differential diagnosis with migraine is crucial to avoid the administration of vasoconstrictors.
Related Concept Videos
Coronary Artery Disease III: Clinical Manifestations
Introduction Cardiac Emergencies
Photoreceptors and Visual Pathways
Angina III: Clinical Manifestations and Assessment
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
