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Dynamic ensemble coding of saccades in the monkey superior colliculus.

H H L M Goossens1, A J Van Opstal

  • 1Department of Medical Physics and Biophysics, Institute for Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. J.Goossens@science.ru.nl

Journal of Neurophysiology
|December 24, 2005
PubMed
Summary

The superior colliculus (SC) uses dynamic ensemble coding for eye movements. Each neuron

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Area of Science:

  • Neuroscience
  • Oculomotor Systems
  • Computational Neuroscience

Background:

  • The deeper layers of the midbrain superior colliculus (SC) contain a topographic motor map for saccades.
  • The precise mechanism by which the brain stem decodes dynamic SC output remains unclear.

Purpose of the Study:

  • To test a novel dynamic ensemble-coding model for saccade generation.
  • To investigate how the brain stem decodes the SC's output for eye movement commands.

Main Methods:

  • Analysis of saccade-related neural responses in the monkey SC.
  • Testing a dynamic ensemble-coding model proposing fixed contributions per spike.
  • Utilizing a linear feedback model of the brain stem driven by SC firing patterns.

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Main Results:

  • Cumulative spike counts in SC cell bursts correlate with eye displacement along straight trajectories.
  • This relationship holds for normal and perturbed saccades, depending on saccade metrics.
  • A linear brain stem model driven by SC activity accurately predicts 2D saccade trajectories and kinematics.

Conclusions:

  • The SC may function as a nonlinear, vectorial saccade generator.
  • It appears to program optimal, straight eye-movement trajectories.
  • Dynamic ensemble coding provides a framework for understanding SC output decoding.