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Related Experiment Videos

Signaling mechanisms regulating endothelial permeability.

Dolly Mehta1, Asrar B Malik

  • 1Center of Lung and Vascular Biology, Dept. of Pharmacology (M/C 868), University of Illinois, 835 S. Wolcott Avenue, Chicago, IL 60612, USA.

Physiological Reviews
|December 24, 2005
PubMed
Summary

Endothelial cells regulate fluid balance and nutrient transport via paracellular and transcellular pathways. This review details signaling mechanisms controlling these vital endothelial transport routes.

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Area of Science:

  • Vascular Biology
  • Cell Physiology
  • Biochemistry

Background:

  • Microvascular endothelial cells form a critical barrier between blood and tissues.
  • They regulate fluid balance, nutrient supply, and respond to various signals.
  • Endothelial semipermeability is key for tissue fluid homeostasis.

Purpose of the Study:

  • To review and analyze signaling mechanisms regulating endothelial transport pathways.
  • To highlight recent data on paracellular and transcellular transport regulation.
  • To explore the role of caveolae in solute transport.

Main Methods:

  • Analysis of genetic, physiological, cellular, and morphological studies.
  • Review of signaling pathways controlling endothelial transport.

Related Experiment Videos

  • Examination of interendothelial junctions and vesicular transport.

    • Main Results:

    • Endothelial cells dynamically regulate paracellular and transcellular transport.
    • Interendothelial junctions limit paracellular protein passage.
    • Transcellular albumin transport occurs via transcytosis involving caveolae.

    Conclusions:

    • Signaling pathways critically control both paracellular and transcellular endothelial transport.
    • Understanding these mechanisms is vital for maintaining tissue fluid homeostasis.
    • Recent research illuminates the complex regulation of endothelial permeability.