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Updated: Aug 14, 2026
Corneal Donor Tissue Preparation for Endothelial Keratoplasty
Published on: June 12, 2012
Corneal ulceration and perforation with ketorolac tromethamine (Acular) use after PRK
Shahzad I Mian1, Anjali Gupta, Roberto Pineda
1University of Michigan, W. K. Kellogg Eye Center, Ann Arbor, Michigan 48105, USA. smian@med.umich.edu
Purpose:
To report a case of corneal ulceration and perforation after PRK connected with high doses of ketorolac tromethamine (Acula).
Methods:
A 31-year-old man presented 5 days after PRK in the left eye with corneal ulceration and perforation requiring penetrating keratoplasty. The patient admitted to using Acular every hour, ciprofloxocin every hour, and prednisolone acetate 1% QID postoperatively.
Results:
Laboratory tests, including corneal cultures, were normal. A diagnosis of corneal ulceration secondary to incorrect use of high-dose ketorolac tromethamine was made.
Conclusion:
Judicious patient counseling is recommended when using topical NSAIDs in the setting of PRK.
