Related Experiment Video
Updated: Aug 14, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Treatment with topical interferon alone in severe conjunctivo-corneal neoplasia]
D Díaz-Valle1, J M Benítez-del-Castillo, T Díaz-Valle
1Unidad de Córnea e Inflamación Ocular, Hospital General de Móstoles, Madrid, Spain. ddiazval@nacom.es
Case Report:
A 78-year-old man was referred for evaluation of a limbic lesion in his left eye. This had a gelatinous appearance and an extension of 240 degrees . The lesion was clinically diagnosed to be a conjunctival and corneal intraepithelial neoplasia (CIN). Topical treatment with interferon alpha2b (INFalpha2b) four times daily was started and continued until the lesion had completely resolved at 4 months.
Discussion:
Topical INFalpha2b alone may be a safe and effective treatment of CIN instead of the other classic alternatives such as surgical excision with cryotherapy, which could induce the development of severe limbic deficiency in cases with extensive disease.
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