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Pericyte biology and diseases
1Department of Internal Medicine III, Kurume University School of Medicine, Japan. shoichi@med.kurume-u.ac.jp
International Journal of Tissue Reactions
|December 24, 2005
Summary
Pericytes, crucial cells in microvessels, are vital for maintaining vascular health. Their loss or dysfunction contributes to serious diseases like diabetic retinopathy and atherosclerosis.
Area of Science:
- Vascular Biology
- Cell Biology
- Pathophysiology
Background:
- Microvessels consist of endothelial cells and pericytes.
- Pericytes, mesodermal cells, partially envelop small vessel endothelial cells.
- Historically viewed as smooth muscle cell counterparts regulating capillary tone.
Purpose of the Study:
- To review pericyte biology.
- To explore the pathological role of pericyte loss or dysfunction.
- To examine pericyte involvement in diabetic retinopathy, atherosclerosis, and tumor angiogenesis.
Main Methods:
- Literature review of pericyte biology.
- Analysis of pericyte function in homeostasis.
- Examination of pericyte's role in disease pathogenesis.
Main Results:
- Pericytes are essential for microvascular homeostasis.
- Pericyte loss or dysfunction is implicated in various disorders.
- Evidence links pericytes to diabetic retinopathy, atherosclerosis, and tumor angiogenesis.
Conclusions:
- Pericytes have critical roles beyond capillary tone regulation.
- Pericyte dysfunction is a key factor in several pathologies.
- Understanding pericyte biology is vital for treating microvascular diseases.