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Acute pancreatitis associated with omeprazole.

S S Youssef1, S B Iskandar, J Scruggs

  • 1James H. Quillen Veterans Affairs and James H. Quillen College of Medicine, Johnson City, TN, USA.

International Journal of Clinical Pharmacology and Therapeutics
|December 24, 2005
PubMed
Summary

Proton pump inhibitors (PPIs) effectively treat acid-related disorders. However, this case report details a rare instance of acute pancreatitis linked to omeprazole, a commonly used PPI.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Proton pump inhibitors (PPIs) are widely used for acid-peptic disorders, offering superior gastric acid suppression compared to H2-receptor blockers.
  • PPIs are generally considered safe with minimal side effects and few drug interactions, making them suitable for long-term use.
  • Established indications include gastroesophageal reflux disease, peptic ulcer disease, and NSAID-induced gastropathy.

Observation:

  • This report describes a rare adverse event associated with PPI therapy.
  • A patient developed acute pancreatitis during treatment with omeprazole.

Findings:

  • Proton pump inhibitors (PPIs) demonstrate significant efficacy in managing acid-related gastrointestinal conditions.
  • While generally safe, PPIs can rarely be associated with serious adverse events.

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  • Acute pancreatitis is identified as a potential, albeit uncommon, side effect of omeprazole.

    • Implications:

    • Clinicians should be aware of rare but severe side effects associated with PPIs.
    • Further investigation may be warranted to understand the mechanism linking PPIs to pancreatitis.
    • This case highlights the importance of considering drug-induced causes in pancreatitis diagnosis.