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Updated: Aug 14, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
[C-reactive protein in the acute phase of ischemic stroke]
José Carlos Arévalo-Lorido1, Juana Carretero-Gómez, José María Calvo-Romero
1Servicio de Medicina Interna, Hospital Comarcal de Zafra, Badajoz, España. jocarlor@inicia.es
Background And Objective:
We aimed to assess the prognostic importance of C-reactive protein (CRP) in the acute phase of ischemic stroke in-patients.
Patients And Method:
One hundred and seventeen patients within 48 h after index ischemic stroke were included. CRP levels and blood samples were obtained at this time, and a brain computerized tomography or magnetic resonance imaging were performed. Neurological and functional disability were evaluated and patients were divided according to the outcome into the following categories: transient ischemic attack, favorable stroke, and non-favorable stroke.
Results:
32 in-patients were classified as transient ischemic attack, 31 as favourable stroke, and 54 as non-favorable stroke. There was a worsening in neurological (p < 0.0001) and functional (p < 0.005) disabilities from the TIA group to non-favorable stroke. The CRP mean, by category, was 1.7, 1.07 and 3.6 mg/dl, respectively (p < 0.0001).
Conclusions:
We found increased levels of CRP in the non-favorable stroke category, that was related with neurological and functional disabilities, and with radiological findings, mainly when levels were greater than 3.6 (0.49) mg/dl.
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